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Projecting the performance of risk prediction based on polygenic analyses of genome-wide association studies
We report a new model to project the predictive performance of polygenic models based on the number and distribution of effect sizes for the underlying susceptibility alleles and the size of the training dataset. Using estimates of effect-size distribution and heritability derived from current studi...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2013
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3729116/ https://ncbi.nlm.nih.gov/pubmed/23455638 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2579 |
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