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Estimation of effect size distribution from genome-wide association studies and implications for future discoveries

We report a set of tools to estimate the number of susceptibility loci and the distribution of their effect sizes for a trait on the basis of discoveries from existing genome-wide association studies (GWASs). We propose statistical power calculations for future GWASs using estimated distributions of...

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Veröffentlicht in:Nat Genet
Hauptverfasser: Park, Ju-Hyun, Wacholder, Sholom, Gail, Mitchell H, Peters, Ulrike, Jacobs, Kevin B, Chanock, Stephen J, Chatterjee, Nilanjan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4615599/
https://ncbi.nlm.nih.gov/pubmed/20562874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.610
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