Estimation of effect size distribution from genome-wide association studies and implications for future discoveries

We report a set of tools to estimate the number of susceptibility loci and the distribution of their effect sizes for a trait on the basis of discoveries from existing genome-wide association studies (GWASs). We propose statistical power calculations for future GWASs using estimated distributions of...

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Publicado en:Nat Genet
Main Authors: Park, Ju-Hyun, Wacholder, Sholom, Gail, Mitchell H, Peters, Ulrike, Jacobs, Kevin B, Chanock, Stephen J, Chatterjee, Nilanjan
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4615599/
https://ncbi.nlm.nih.gov/pubmed/20562874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.610
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