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Spongian diterpenoids inhibit androgen receptor activity

Androgen receptor (AR) is a ligand-activated transcription factor and a validated drug target for all stages of prostate cancer. Antiandrogens compete with physiological ligands for AR ligand-binding domain (LBD). High-throughput screening of a marine natural product library for small molecules that...

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Bibliografische gegevens
Hoofdauteurs: Yang, Yu Chi, Meimetis, Labros G, Tien, Amy H, Mawji, Nasrin R, Carr, Gavin, Wang, Jun, Andersen, Raymond J, Sadar, Marianne D
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2013
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3729039/
https://ncbi.nlm.nih.gov/pubmed/23443807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-12-0978
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