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AAV9 administered systemically after reperfusion preferentially targets cardiomyocytes in the infarct border zone with pharmacodynamics suitable for the attenuation of left ventricular remodeling
OBJECTIVE: Adeno-associated virus serotype 9 (AAV9) vectors provide efficient and uniform gene expression to normal myocardium following systemic administration with kinetics that approach steady state within 2–3 weeks. However, due to the delayed onset of gene expression, AAV vectors have not previ...
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| Główni autorzy: | , , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2012
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3729029/ https://ncbi.nlm.nih.gov/pubmed/23065925 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jgm.2673 |
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