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Synthesis and Anticancer Activity of Epipolythiodiketopiperazine Alkaloids

The epipolythiodiketopiperazine (ETP) alkaloids are a highly complex class of natural products with potent anticancer activity. Herein, we report the application of a flexible and scalable synthesis, allowing the construction of dozens of ETP derivatives. The evaluation of these compounds against ca...

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Detalhes bibliográficos
Main Authors: Boyer, Nicolas, Morrison, Karen C., Kim, Justin, Hergenrother, Paul J., Movassaghi, Mohammad
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3728915/
https://ncbi.nlm.nih.gov/pubmed/23914293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C3SC50174D
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