Antisense Reduction of Tau in Adult Mice Protects against Seizures

Tau, a microtubule-associated protein, is implicated in the pathogenesis of Alzheimer's Disease (AD) in regard to both neurofibrillary tangle formation and neuronal network hyperexcitability. The genetic ablation of tau substantially reduces hyperexcitability in AD mouse lines, induced seizure...

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Detalhes bibliográficos
Main Authors: DeVos, Sarah L., Goncharoff, Dustin K., Chen, Guo, Kebodeaux, Carey S., Yamada, Kaoru, Stewart, Floy R., Schuler, Dorothy R., Maloney, Susan E., Wozniak, David F., Rigo, Frank, Bennett, C. Frank, Cirrito, John R., Holtzman, David M., Miller, Timothy M.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3728694/
https://ncbi.nlm.nih.gov/pubmed/23904623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2107-13.2013
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