Antisense Reduction of Tau in Adult Mice Protects against Seizures

Tau, a microtubule-associated protein, is implicated in the pathogenesis of Alzheimer's Disease (AD) in regard to both neurofibrillary tangle formation and neuronal network hyperexcitability. The genetic ablation of tau substantially reduces hyperexcitability in AD mouse lines, induced seizure...

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書誌詳細
主要な著者: DeVos, Sarah L., Goncharoff, Dustin K., Chen, Guo, Kebodeaux, Carey S., Yamada, Kaoru, Stewart, Floy R., Schuler, Dorothy R., Maloney, Susan E., Wozniak, David F., Rigo, Frank, Bennett, C. Frank, Cirrito, John R., Holtzman, David M., Miller, Timothy M.
フォーマット: Artigo
言語:Inglês
出版事項: Society for Neuroscience 2013
主題:
Articles
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3728694/
https://ncbi.nlm.nih.gov/pubmed/23904623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2107-13.2013
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