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Compound A, a Selective Glucocorticoid Receptor Modulator, Enhances Heat Shock Protein Hsp70 Gene Promoter Activation

Compound A possesses glucocorticoid receptor (GR)-dependent anti-inflammatory properties. Just like classical GR ligands, Compound A can repress NF-κB-mediated gene expression. However, the monomeric Compound A-activated GR is unable to trigger glucocorticoid response element-regulated gene expressi...

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Main Authors: Beck, Ilse M., Drebert, Zuzanna J., Hoya-Arias, Ruben, Bahar, Ali A., Devos, Michael, Clarisse, Dorien, Desmet, Sofie, Bougarne, Nadia, Ruttens, Bart, Gossye, Valerie, Denecker, Geertrui, Lievens, Sam, Bracke, Marc, Tavernier, Jan, Declercq, Wim, Gevaert, Kris, Berghe, Wim Vanden, Haegeman, Guy, De Bosscher, Karolien
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2013
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גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3728325/
https://ncbi.nlm.nih.gov/pubmed/23935933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0069115
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