Compound A, a Selective Glucocorticoid Receptor Modulator, Enhances Heat Shock Protein Hsp70 Gene Promoter Activation

Compound A possesses glucocorticoid receptor (GR)-dependent anti-inflammatory properties. Just like classical GR ligands, Compound A can repress NF-κB-mediated gene expression. However, the monomeric Compound A-activated GR is unable to trigger glucocorticoid response element-regulated gene expressi...

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Hauptverfasser: Beck, Ilse M., Drebert, Zuzanna J., Hoya-Arias, Ruben, Bahar, Ali A., Devos, Michael, Clarisse, Dorien, Desmet, Sofie, Bougarne, Nadia, Ruttens, Bart, Gossye, Valerie, Denecker, Geertrui, Lievens, Sam, Bracke, Marc, Tavernier, Jan, Declercq, Wim, Gevaert, Kris, Berghe, Wim Vanden, Haegeman, Guy, De Bosscher, Karolien
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3728325/
https://ncbi.nlm.nih.gov/pubmed/23935933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0069115
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