DNA methylation of the glucagon-like peptide 1 receptor (GLP1R) in human pancreatic islets

BACKGROUND: Insulin secretion is enhanced upon the binding of Glucagon-like peptide-1 (GLP-1) to its receptor (GLP1R) in pancreatic β cells. Although a reduced expression of GLP1R in pancreatic islets from type 2 diabetic patients and hyperglycaemic rats has been established, it is still unknown if...

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Autori principali: Hall, Elin, Dayeh, Tasnim, Kirkpatrick, Clare L, Wollheim, Claes B, Dekker Nitert, Marloes, Ling, Charlotte
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3727960/
https://ncbi.nlm.nih.gov/pubmed/23879380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2350-14-76
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