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Effects of hyperglycemia and aging on nuclear sirtuins and DNA damage of mouse hepatocytes

Hyperglycemia, like aging, induces chromatin remodeling in mouse hepatocytes in comparison to normoglycemia and younger age, respectively. Changes in glucose metabolism also affect the action and expression of sirtuins, promoting changes in chromatin conformation and dynamics. Here we investigate th...

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Hauptverfasser: Ghiraldini, Flávia Gerelli, Crispim, Ana Carolina Vitolo, Mello, Maria Luiza Silveira
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Cell Biology 2013
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3727938/
https://ncbi.nlm.nih.gov/pubmed/23761075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E13-04-0186
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