Association Between BRCA1 and BRCA2 Mutations and Survival in Women with Invasive Epithelial Ovarian Cancer

CONTEXT: Approximately 10 percent of women with invasive epithelial ovarian cancer (EOC) carry deleterious germline mutations in BRCA1 or BRCA2. A recent report suggested that BRCA2 related EOC was associated with an improved prognosis, but the effect of BRCA1 remains unclear. OBJECTIVE: To characte...

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Hlavní autoři: Bolton, Kelly L., Chenevix-Trench, Georgia, Goh, Cindy, Sadetzki, Siegal, Ramus, Susan J., Karlan, Beth Y., Lambrechts, Diether, Despierre, Evelyn, Barrowdale, Daniel, McGuffog, Lesley, Healey, Sue, Easton, Douglas F., Sinilnikova, Olga, Benitez, Javier, García, María J., Neuhausen, Susan, Gail, Mitchell H., Hartge, Patricia, Peock, Susan, Frost, Debra, Evans, D. Gareth, Eeles, Ros, Godwin, Andrew K., Daly, Mary B., Kwong, Ava, Ma, Edmond SK, Lázaro, Conxi, Blanco, Ignacio, Montagna, Marco, D’Andrea, Emma, Nicoletto, Ornella, Investigators, kConFab, Johnatty, Sharon E., Kjær, Susanne Krüger, Jensen, Allan, Høgdall, Estrid, Goode, Ellen L., Fridley, Brooke L., Loud, Jennifer T., Greene, Mark H., Mai, Phuong L., Chetrit, Angela, Lubin, Flora, Hirsh-Yechezkel, Galit, Glendon, Gord, Andrulis, Irene L., Toland, Amanda E., Senter, Leigha, Gore, Martin E., Gourley, Charlie, Michie, Caroline O, Song, Honglin, Tyrer, Jonathan, Whittemore, Alice S., McGuire, Valerie, Sieh, Weiva, Kristoffersson, Ulf, Olsson, Håkan, Borg, Åke, Levine, Douglas A., Steele, Linda, Beattie, Mary S., Chan, Salina, Nussbaum, Robert, Moysich, Kirsten B., Gross, Jenny, Cass, Ilana, Walsh, Christine, Li, Andrew J., Leuchter, Ronald, Gordon, Ora, Garcia-Closas, Montserrat, Gayther, Simon A., Chanock, Stephen J., Antoniou, Antonis C., Pharoah, Paul D.P.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3727895/
https://ncbi.nlm.nih.gov/pubmed/22274685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jama.2012.20
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