Pooled analysis indicates that the GSTT1 deletion, GSTM1 deletion, and GSTP1 Ile105Val polymorphisms do not modify breast cancer risk in BRCA1 and BRCA2 mutation carriers

The GSTP1, GSTM1, and GSTT1 detoxification genes all have functional polymorphisms that are common in the general population. A single study of 320 BRCA1/2 carriers previously assessed their effect in BRCA1 or BRCA2 mutation carriers. This study showed no evidence for altered risk of breast cancer f...

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Détails bibliographiques
Auteurs principaux: Spurdle, Amanda B., Fahey, Paul, Chen, Xiaoqing, McGuffog, Lesley, Easton, Douglas, Peock, Susan, Cook, Margaret, Simard, Jacques, Rebbeck, Tim R., Antoniou, Antonis C., Chenevix-Trench, Georgia
Format: Artigo
Langue:Inglês
Publié: 2009
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3074275/
https://ncbi.nlm.nih.gov/pubmed/19921428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-009-0601-0
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