Peptide-Mediated Inhibition of Mitogen-Activated Protein Kinase–Activated Protein Kinase–2 Ameliorates Bleomycin-Induced Pulmonary Fibrosis

Mitogen-activated protein kinase–activated protein kinase–2 (MAPKAPK2, or MK2), a serine/threonine kinase downstream of p38 mitogen–activated protein kinase, has been implicated in inflammation and fibrosis. Compared with pathologically normal lung tissue, significantly higher concentrations of acti...

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Hlavní autoři: Vittal, Ragini, Fisher, Amanda, Gu, Hongmei, Mickler, Elizabeth A., Panitch, Alyssa, Lander, Cynthia, Cummings, Oscar W., Sandusky, George E., Wilkes, David S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Thoracic Society 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3727887/
https://ncbi.nlm.nih.gov/pubmed/23470623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2012-0389OC
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