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Scaling Pharmacodynamics from In Vitro and Preclinical Animal Studies to Humans

An important feature of mechanism-based pharmacokinetic/pharmacodynamic (PK/PD) models is the identification of drug- and system-specific factors that determine the intensity and time-course of pharmacological effects. This provides an opportunity to integrate information obtained from in vitro bioa...

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Hlavní autoři: Mager, Donald E., Woo, Sukyung, Jusko, William J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3727168/
https://ncbi.nlm.nih.gov/pubmed/19252333
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