Chronic hypoxia selectively enhances L- and T-type voltage-dependent Ca(2+) channel activity in pulmonary artery by upregulating Ca(v)1.2 and Ca(v)3.2

Hypoxia-induced pulmonary hypertension (HPH) is characterized by sustained pulmonary vasoconstriction and vascular remodeling, both of which are mediated by pulmonary artery smooth muscle cell (PASMC) contraction and proliferation, respectively. An increase in cytosolic Ca(2+) concentration ([Ca(2+)...

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Autori principali: Wan, Jun, Yamamura, Aya, Zimnicka, Adriana M., Voiriot, Guillaume, Smith, Kimberly A., Tang, Haiyang, Ayon, Ramon J., Choudhury, Moumita S. R., Ko, Eun A., Wang, Jun, Wang, Chen, Makino, Ayako, Yuan, Jason X.-J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3726947/
https://ncbi.nlm.nih.gov/pubmed/23686856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00313.2012
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