Modulation of the Akt Pathway Reveals a Novel Link with PERK/eIF2α, which Is Relevant during Hypoxia

The unfolded protein response (UPR) and the Akt signaling pathway share several regulatory functions and have the capacity to determine cell outcome under specific conditions. However, both pathways have largely been studied independently. Here, we asked whether the Akt pathway regulates the UPR. To...

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Detalhes bibliográficos
Main Authors: Blaustein, Matías, Pérez-Munizaga, Daniela, Sánchez, Manuel Alejandro, Urrutia, Carolina, Grande, Alicia, Risso, Guillermo, Srebrow, Anabella, Alfaro, Jennifer, Colman-Lerner, Alejandro
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3726764/
https://ncbi.nlm.nih.gov/pubmed/23922774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0069668
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