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Macromolecular Crowding as a Suppressor of Human IAPP Fibril Formation and Cytotoxicity

The biological cell is known to exhibit a highly crowded milieu, which significantly influences protein aggregation and association processes. As several cell degenerative diseases are related to the self-association and fibrillation of amyloidogenic peptides, understanding of the impact of macromol...

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Detalhes bibliográficos
Main Authors: Seeliger, Janine, Werkmüller, Alexander, Winter, Roland
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3726762/
https://ncbi.nlm.nih.gov/pubmed/23922768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0069652
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