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Role of Minor Groove Width and Hydration Pattern on Amsacrine Interaction with DNA
Amsacrine is an anilinoacridine derivative anticancer drug, used to treat a wide variety of malignancies. In cells, amsacrine poisons topoisomerase 2 by stabilizing DNA-drug-enzyme ternary complex. Presence of amsacrine increases the steady-state concentration of these ternary complexes which in tur...
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| Hlavní autoři: | , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Public Library of Science
2013
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3726726/ https://ncbi.nlm.nih.gov/pubmed/23922861 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0069933 |
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