Deoxyguanosine Triphosphate as a Possible Toxic Metabolite in the Immunodeficiency Associated with Purine Nucleoside Phosphorylase Deficiency

Purine nucleoside phosphorylase (PNP) deficiency is associated with a severe defect in thymus-derived (T)-lymphocyte function combined with normal bone marrow-derived (B)-lymphocyte function. To investigate the role of this enzyme deficiency in the resulting immune dysfunction, we measured the level...

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Detalles Bibliográficos
Main Authors: Cohen, Amos, Gudas, Lorraine J., Ammann, Arthur J., Staal, Gerard E. J., Martin, David W.
Formato: Artigo
Idioma:Inglês
Publicado: 1978
Assuntos:
Rapid Publications
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC372663/
https://ncbi.nlm.nih.gov/pubmed/96138
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