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SIRT1 Promotes RGC Survival and Delays Loss of Function Following Optic Nerve Crush

PURPOSE. Activation of SIRT1 deacetylase prevents retinal ganglion cell (RGC) loss in experimental optic neuritis, an inflammatory optic neuropathy. While mechanisms of this effect are not known, evidence suggests it involves reduction of oxidative stress. We hypothesized that SIRT1 reduces RGC loss...

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書誌詳細
主要な著者: Zuo, Ling, Khan, Reas S., Lee, Vivian, Dine, Kimberly, Wu, Wen, Shindler, Kenneth S.
フォーマット: Artigo
言語:Inglês
出版事項: The Association for Research in Vision and Ophthalmology 2013
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オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3726244/
https://ncbi.nlm.nih.gov/pubmed/23821198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.13-12157
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