Somitic disruption of GNAS in chick embryos mimics progressive osseous heteroplasia

Progressive osseous heteroplasia (POH) is a rare developmental disorder of heterotopic ossification (HO) caused by heterozygous inactivating germline mutations in the paternal allele of the GNAS gene. Interestingly, POH lesions have a bewildering mosaic distribution. Using clinical, radiographic, an...

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Hauptverfasser: Cairns, Dana M., Pignolo, Robert J., Uchimura, Tomoya, Brennan, Tracy A., Lindborg, Carter M., Xu, Meiqi, Kaplan, Frederick S., Shore, Eileen M., Zeng, Li
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3726175/
https://ncbi.nlm.nih.gov/pubmed/23863715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI69746
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