Pharmacokinetic-Pharmacodynamic Disease Progression Model for Effect of Etanercept in Lewis Rats with Collagen-Induced Arthritis

PURPOSE: To develop a pharmacokinetic-pharmacodynamic disease progression (PK/PD/DIS) model to characterize the effect of etanercept in collagen-induced arthritis (CIA) rats on rheumatoid arthritis (RA) progression. METHODS: The CIA rats received either 5 mg/kg intravenous (IV), 1 mg/kg IV, or 5 mg/...

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Main Authors: Lon, Hoi-Kei, Liu, Dongyang, Zhang, Qi, DuBois, Debra C., Almon, Richard R., Jusko, William J.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3726066/
https://ncbi.nlm.nih.gov/pubmed/21360252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-011-0396-7
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