Population pharmacokinetic–pharmacodynamic–disease progression model for effects of anakinra in Lewis rats with collagen-induced arthritis

A population pharmacokinetic–pharmacodynamic–disease progression (PK/PD/DIS) model was developed to characterize the effects of anakinra in collagen-induced arthritic (CIA) rats and explore the role of interleukin-1β (IL-1β) in rheumatoid arthritis. The CIA rats received either vehicle, or anakinra...

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Bibliografiske detaljer
Main Authors: Liu, Dongyang, Lon, Hoi-Kei, DuBois, Debra C., Almon, Richard R., Jusko, William J.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3407879/
https://ncbi.nlm.nih.gov/pubmed/22002845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10928-011-9219-z
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