Curative Effects of Thiacremonone against Acetaminophen-Induced Acute Hepatic Failure via Inhibition of Proinflammatory Cytokines Production and Infiltration of Cytotoxic Immune Cells and Kupffer Cells

High doses of acetaminophen (APAP; N-acetyl-p-aminophenol) cause severe hepatotoxicity after metabolic activation by cytochrome P450 2E1. This study was undertaken to examine the preventive effects of thiacremonone, a compound extracted from garlic, on APAP-induced acute hepatic failure in male C57B...

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Bibliographic Details
Main Authors: Kim, Yu Ri, Lee, Nam Jin, Ban, Jung Ok, Yoo, Hwan Soo, Lee, Yong Moon, Yoon, Yeo Pyo, Eum, So Young, Jeong, Heon Sang, Yoon, Do-young, Han, Sang Bae, Hong, Jin Tae
Format: Artigo
Language:Inglês
Published: Hindawi Publishing Corporation 2013
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3725907/
https://ncbi.nlm.nih.gov/pubmed/23935693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/974794
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