Brain Oligomeric β-Amyloid but Not Total Amyloid Plaque Burden Correlates With Neuronal Loss and Astrocyte Inflammatory Response in Amyloid Precursor Protein/Tau Transgenic Mice

It has long been assumed that β-amyloid (Aβ) had to assemble into fibrillar amyloid plaques to exert its neurotoxic effects in Alzheimer disease. An alternative hypothesis is that soluble oligomers of Aβ play a much larger role in neuronal damage than the insoluble component. We have tested these co...

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Main Authors: DaRocha-Souto, Bibiana, Scotton, Thomas C., Coma, Mireia, Serrano-Pozo, Alberto, Hashimoto, Tadafumi, Serenó, Lidia, Rodríguez, Marta, Sánchez, Belen, Hyman, Bradley T., Gómez-Isla, Teresa
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3725771/
https://ncbi.nlm.nih.gov/pubmed/21487307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/NEN.0b013e318217a118
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