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Role for intestinal CYP2E1 in alcohol-induced circadian gene-mediated intestinal hyperpermeability
We have shown that alcohol increases Caco-2 intestinal epithelial cell monolayer permeability in vitro by inducing the expression of redox-sensitive circadian clock proteins CLOCK and PER2 and that these proteins are necessary for alcohol-induced hyperpermeability. We hypothesized that alcohol metab...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Physiological Society
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3725682/ https://ncbi.nlm.nih.gov/pubmed/23660503 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00354.2012 |
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