Role for intestinal CYP2E1 in alcohol-induced circadian gene-mediated intestinal hyperpermeability

We have shown that alcohol increases Caco-2 intestinal epithelial cell monolayer permeability in vitro by inducing the expression of redox-sensitive circadian clock proteins CLOCK and PER2 and that these proteins are necessary for alcohol-induced hyperpermeability. We hypothesized that alcohol metab...

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Bibliografiske detaljer
Main Authors: Forsyth, Christopher B., Voigt, Robin M., Shaikh, Maliha, Tang, Yueming, Cederbaum, Arthur I., Turek, Fred W., Keshavarzian, Ali
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2013
Fag:
Mucosal Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3725682/
https://ncbi.nlm.nih.gov/pubmed/23660503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00354.2012
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