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Inhibition of ROMK channels by low extracellular K(+) and oxidative stress

We tested the hypothesis that low luminal K(+) inhibits the activity of ROMK channels in the rat cortical collecting duct. Whole-cell voltage-clamp measurements of the component of outward K(+) current inhibited by the bee toxin Tertiapin-Q (I(SK)) showed that reducing the bath concentration ([K(+)]...

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Detalhes bibliográficos
Main Authors: Frindt, Gustavo, Li, Hui, Sackin, Henry, Palmer, Lawrence G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3725663/
https://ncbi.nlm.nih.gov/pubmed/23678039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00185.2013
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