Reactive oxygen species and IRF1 stimulate IFNα production by proximal tubules during ischemic AKI

We previously reported that expression of the transcription factor interferon regulatory factor 1 (IRF1) is an early, critical maladaptive signal expressed by renal tubules during murine ischemic acute kidney injury (AKI). We now show that IRF1 mediates signals from reactive oxygen species (ROS) gen...

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Autori principali: Winterberg, Pamela D., Wang, Yanxia, Lin, Keng-Mean, Hartono, John R., Nagami, Glenn T., Zhou, Xin J., Shelton, John M., Richardson, James A., Lu, Christopher Y.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3725662/
https://ncbi.nlm.nih.gov/pubmed/23657854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00487.2012
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