CNGA3 achromatopsia-associated mutation potentiates the phosphoinositide sensitivity of cone photoreceptor CNG channels by altering intersubunit interactions

Cyclic nucleotide-gated (CNG) channels are critical for sensory transduction in retinal photoreceptors and olfactory receptor cells; their activity is modulated by phosphoinositides (PIP(n)) such as phosphatidylinositol 4,5-bisphosphate (PIP(2)) and phosphatidylinositol 3,4,5-trisphosphate (PIP(3))....

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Bibliographic Details
Main Authors: Dai, Gucan, Varnum, Michael D.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2013
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3725626/
https://ncbi.nlm.nih.gov/pubmed/23552282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00037.2013
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