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Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3(+) T Regulatory Cells

Helios, a member of the Ikaros transcription factor family, is preferentially expressed at the mRNA level by regulatory T cells (Treg cells). We evaluated Helios protein expression using a newly generated mAb and demonstrated that it is expressed in all thymocytes at the double negative 2 stage of t...

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Hlavní autoři: Thornton, Angela M., Korty, Patricia E., Tran, Dat Q., Wohlfert, Elizabeth A., Murray, Patrick E., Belkaid, Yasmine, Shevach, Ethan M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3725574/
https://ncbi.nlm.nih.gov/pubmed/20181882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0904028
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