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Geminin deploys multiple mechanisms to regulate Cdt1 before cell division thus ensuring the proper execution of DNA replication

Cdc10-dependent transcript 1 (Cdt1) is an essential DNA replication protein whose accumulation at the end of the cell cycle promotes the formation of pre-replicative complexes and replication in the next cell cycle. Geminin is thought to be involved in licensing replication by promoting the accumula...

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Detalhes bibliográficos
Main Authors: Ballabeni, Andrea, Zamponi, Raffaella, Moore, Jodene K., Helin, Kristian, Kirschner, Marc W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3725105/
https://ncbi.nlm.nih.gov/pubmed/23836640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1310677110
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