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Loss of Geminin induces rereplication in the presence of functional p53
Strict regulation of DNA replication is essential to ensure proper duplication and segregation of chromosomes during the cell cycle, as its deregulation can lead to genomic instability and cancer. Thus, eukaryotic organisms have evolved multiple mechanisms to restrict DNA replication to once per cel...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The Rockefeller University Press
2004
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2172361/ https://ncbi.nlm.nih.gov/pubmed/15159417 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200403106 |
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