CD22 ligand-binding and signaling domains reciprocally regulate B-cell Ca(2+) signaling

A high proportion of human B cells carry B-cell receptors (BCRs) that are autoreactive. Inhibitory receptors such as CD22 can downmodulate autoreactive BCR responses. With its extracellular domain, CD22 binds to sialic acids in α2,6 linkages in cis, on the surface of the same B cell or in trans, on...

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Bibliografiska uppgifter
Huvudupphovsmän: Müller, Jennifer, Obermeier, Ingrid, Wöhner, Miriam, Brandl, Carolin, Mrotzek, Sarah, Angermüller, Sieglinde, Maity, Palash C., Reth, Michael, Nitschke, Lars
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2013
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3725054/
https://ncbi.nlm.nih.gov/pubmed/23836650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1304888110
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