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Thermodynamic framework for identifying free energy inventories of enzyme catalytic cycles

Pauling’s suggestion that enzymes are complementary in structure to the activated complexes of the reactions they catalyze has provided the conceptual basis to explain how enzymes obtain their fantastic catalytic prowess, and has served as a guiding principle in drug design for over 50 y. However, t...

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Detalhes bibliográficos
Main Authors: Fried, Stephen D., Boxer, Steven G.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3725039/
https://ncbi.nlm.nih.gov/pubmed/23840058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1310964110
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