Study of factors causing excess protoporphyrin accumulation in cultured skin fibroblasts from patients with protoporphyria.
The activity of heme synthetase, which catalyzes the chelation of ferrous iron to protoporphyrin to form heme, is deficient in sonicates of skin fibroblasts cultured from patients with protoporphyria. During culture in Eagle's medium supplemented with fetal calf serum, these cells do not accumulate...
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| Publicado no: | J Clin Invest |
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| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
1977
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC372492/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/915001/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI108895 |
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