TGFβ1 Inhibition Increases the Radiosensitivity of Breast Cancer Cells In Vitro and Promotes Tumor Control by Radiation In Vivo

PURPOSE: To determine whether inhibition of TGFβ signaling prior to irradiation sensitizes human and murine cancer cells in vitro and in vivo. EXPERIMENTAL DESIGN: TGFβ-mediated growth and Smad phosphorylation of MCF7, Hs578T, MDA-MB-231, and T47D human breast cancer cell lines were examined and cor...

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Main Authors: Bouquet, Fanny, Pal, Anupama, Pilones, Karsten A., Demaria, Sandra, Hann, Byron, Akhurst, Rosemary J., Babb, Jim S., Lonning, Scott M., DeWyngaert, J. Keith, Formenti, Silvia C., Barcellos-Hoff, Mary Helen
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3724539/
https://ncbi.nlm.nih.gov/pubmed/22028490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-0544
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