Induction of autoimmune diabetes in non-obese diabetic mice requires interleukin-21-dependent activation of autoreactive CD8(+) T cells

Non-obese diabetic (NOD) mice lacking interleukin (IL)-21 or IL-21 receptor do not develop autoimmune type 1 diabetes (T1D). We have shown recently that IL-21 may promote activation of autoreactive CD8(+) T cells by increasing their antigen responsiveness. To investigate the role of IL-21 in activat...

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Detalhes bibliográficos
Main Authors: Chen, X-L, Bobbala, D, Rodriguez, G M, Mayhue, M, Chen, Y-G, Ilangumaran, S, Ramanathan, S
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2013
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3722919/
https://ncbi.nlm.nih.gov/pubmed/23607664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cei.12108
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