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Autophagy master regulator TFEB induces clearance of toxic SERPINA1/α-1-antitrypsin polymers
Deficiency of SERPINA1/AAT [serpin peptidase inhibitor, clade A (α-1 antiproteinase, antitrypsin), member 1/α 1-antitrypsin] results in polymerization and aggregation of mutant SERPINA1 molecules in the endoplasmic reticulum of hepatocytes, triggering liver injury. SERPINA1 deficiency is the most co...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3722318/ https://ncbi.nlm.nih.gov/pubmed/23584152 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.24469 |
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