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Transient domoic acid excitotoxicity increases BDNF expression and activates both MEK- and PKA-dependent neurogenesis in organotypic hippocampal slices
BACKGROUND: We have previously reported evidence of cell proliferation and increased neurogenesis in rat organotypic hippocampal slice cultures (OHSC) after a transient excitotoxic injury to the hippocampal CA1 area induced by low concentrations of the AMPA/kainate agonist domoic acid (DOM). An incr...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
BioMed Central
2013
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3722092/ https://ncbi.nlm.nih.gov/pubmed/23865384 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2202-14-72 |
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