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Molecular basis of cross-species reactivities of human versus porcine CTLA-4
The binding motif of human CTLA-4 is well known to be MYPPPY and for porcine CTLA-4 the binding motif is LYPPPY. Is this single amino acid difference of methionine (M) versus leucine (L) critical for the CTLA-4 binding? Recently, we have reported that the recombinant soluble porcine CTLA-4 was incap...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3721328/ https://ncbi.nlm.nih.gov/pubmed/23602875 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.humimm.2013.04.002 |
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