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Molecular basis of cross-species reactivities of human versus porcine CTLA-4

The binding motif of human CTLA-4 is well known to be MYPPPY and for porcine CTLA-4 the binding motif is LYPPPY. Is this single amino acid difference of methionine (M) versus leucine (L) critical for the CTLA-4 binding? Recently, we have reported that the recombinant soluble porcine CTLA-4 was incap...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Peraino, Jaclyn Stromp, Zhang, Huiping, Li, Guoying, Huang, Christene A., Wang, Zhirui
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2013
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3721328/
https://ncbi.nlm.nih.gov/pubmed/23602875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.humimm.2013.04.002
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