Excess S-adenosylmethionine reroutes phosphatidylethanolamine towards phosphatidylcholine and triglyceride synthesis

Methionine adenosyltransferase 1A (MAT1A) and glycine N-methyltransferase (GNMT) are the primary genes involved in hepatic S-adenosylmethionine (SAMe) synthesis and degradation, respectively. Mat1a ablation in mice induces a decrease in hepatic SAMe, activation of lipogenesis, inhibition of triglyce...

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Autors principals: Martínez-Uña, Maite, Varela-Rey, Marta, Cano, Ainara, Fernández-Ares, Larraitz, Beraza, Naiara, Aurrekoetxea, Igor, Martínez-Arranz, Ibon, García-Rodríguez, Juan L, Buqué, Xabier, Mestre, Daniela, Luka, Zigmund, Wagner, Conrad, Alonso, Cristina, Finnell, Richard H, Lu, Shelly C, Martínez-Chantar, M Luz, Aspichueta, Patricia, Mato, José M
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3720726/
https://ncbi.nlm.nih.gov/pubmed/23505042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.26399
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