C5a Regulates IL-12(+)DC Migration to Induce Pathogenic Th1 and Th17 Cells in Sepsis

OBJECTIVE: It is well known that complement system C5a is excessively activated during the onset of sepsis. However, it is unclear whether C5a can regulate dentritic cells (DCs) to stimulate adaptive immune cells such as Th1 and Th17 in sepsis. METHODS: Sepsis was induced by cecal ligation and punct...

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Main Authors: Ma, Ning, Xing, Chen, Xiao, He, Wang, Yi, Wang, Ke, Hou, Chunmei, Han, Gencheng, Chen, Guojiang, Marrero, Bernadette, Wang, Yujuan, Shen, Beifen, Li, Yan, Wang, Renxi
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3720656/
https://ncbi.nlm.nih.gov/pubmed/23936099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0069779
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