Defects in DNA and globin messenger RNA in homozygotes for hemoglobin Lepore.

Globin messenger RNA (mRNA) isolated from three patients homozygous for hemoglobin Lepore is shown to have a marked reduction of the amount of beta-like globin mRNA (Lepore-globin mRNA sequences) compared with alpha-globin mRNA by molecular hybridization. The relative amounts of alpha- and Lepore mR...

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Publicat a:J Clin Invest
Autors principals: Ramirez, F, Mears, J G, Nudel, U, Bank, A, Luzzatto, L, DiPrisco, G, D'Avino, R, Pepe, G, Camardella, L, Gambino, R, Cimino, R, Quattrin, N
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 1979
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC372009/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/438334/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI109357
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