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Collective epithelial cell invasion overcomes mechanical barriers of collagenous extracellular matrix by a narrow tube-like geometry and MMP14-dependent local softening()

Collective cell invasion (CCI) through interstitial collagenous extracellular matrix (ECM) is crucial to the initial stages of branching morphogenesis, and a hallmark of tissue repair and dissemination of certain tumors. The collagenous ECM acts as a mechanical barrier against CCI. However, the phys...

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Detalhes bibliográficos
Main Authors: Alcaraz, Jordi, Mori, Hidetoshi, Ghajar, Cyrus M., Brownfield, Doug, Galgoczy, Roland, Bissell, Mina J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3719864/
https://ncbi.nlm.nih.gov/pubmed/21993836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c1ib00073j
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