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Prion Replication Elicits Cytopathic Changes in Differentiated Neurosphere Cultures

The molecular mechanisms of prion-induced cytotoxicity remain largely obscure. Currently, only a few cell culture models have exhibited the cytopathic changes associated with prion infection. In this study, we introduced a cell culture model based on differentiated neurosphere cultures isolated from...

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Detalhes bibliográficos
Main Authors: Iwamaru, Yoshifumi, Takenouchi, Takato, Imamura, Morikazu, Shimizu, Yoshihisa, Miyazawa, Kohtaro, Mohri, Shirou, Yokoyama, Takashi, Kitani, Hiroshi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3719834/
https://ncbi.nlm.nih.gov/pubmed/23740992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00572-13
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