Replication Fitness of Multiple Nonnucleoside Reverse Transcriptase-Resistant HIV-1 Variants in the Presence of Etravirine Measured by 454 Deep Sequencing

We applied an efficient method to characterize the relative fitness levels of multiple nonnucleoside reverse transcriptase (NNRTI)-resistant HIV-1 variants by simultaneous competitive culture and 454 deep sequencing. Using this method, we show that the Y181V mutation in the HIV-1 reverse transcripta...

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Hlavní autoři: Brumme, Chanson J., Huber, Kelly D., Dong, Winnie, Poon, Art F. Y., Harrigan, P. Richard, Sluis-Cremer, Nicolas
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2013
Témata:
Vaccines and Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3719830/
https://ncbi.nlm.nih.gov/pubmed/23720723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00335-13
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