Pharmacokinetic-Pharmacodynamic Determinants of Oseltamivir Efficacy Using Data from Phase 2 Inoculation Studies

Given the limited understanding about pharmacokinetic-pharmacodynamic (PK-PD) determinants of oseltamivir efficacy, data from two phase 2 influenza virus inoculation studies were evaluated. Healthy volunteers in studies 1 and 2 were experimentally infected with influenza A/Texas (the concentration o...

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Main Authors: Rayner, C. R., Bulik, C. C., Kamal, M. A., Reynolds, D. K., Toovey, S., Hammel, J. P., Smith, P. F., Bhavnani, S. M., Van Wart, S. A., Ambrose, P. G., Forrest, A.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2013
主題:
Antiviral Agents
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3719781/
https://ncbi.nlm.nih.gov/pubmed/23669386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02440-12
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