Use of Pharmacokinetic-Pharmacodynamic Target Attainment Analyses To Support Phase 2 and 3 Dosing Strategies for Doripenem

A doripenem population pharmacokinetic model and Monte Carlo simulations were utilized for dose regimen decision support for future clinical development. Simulation results predict that 500 mg of doripenem administered over 1 h every 8 h would be effective against bacterial strains with MICs less th...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Bhavnani, Sujata M., Hammel, Jeffrey P., Cirincione, Brenda B., Wikler, Matthew A., Ambrose, Paul G.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2005
Témata:
Clinical Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1195437/
https://ncbi.nlm.nih.gov/pubmed/16127078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.9.3944-3947.2005
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky